PROKR2 : prokineticin receptor 2


Description

The PROKR2 gene, located on chromosome 20, encodes the prokineticin receptor 2, a G protein-coupled receptor (GPCR) that plays a critical role in various physiological processes, particularly during embryonic development. PROKR2 binds to prokineticins, a family of secreted peptides, triggering intracellular signaling pathways that regulate cell proliferation, migration, and differentiation. Its diverse functions extend beyond embryogenesis, influencing adult physiology in areas such as cardiovascular function, energy metabolism, and even neuronal activity. Understanding the intricacies of PROKR2 signaling is crucial for unraveling the complexities of human health and disease.

Associated Diseases

Did you know?

Mutations in the PROKR2 gene are associated with a rare condition called Kallmann syndrome, a genetic disorder characterized by a lack of sexual maturation and anosmia (loss of smell).


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