PROK2 : prokineticin 2
Description
The PROK2 gene, encodes the precursor protein for prokineticin-2 (PK2), a potent peptide hormone that plays a crucial role in regulating gastrointestinal motility, inflammation, and neurogenesis. PK2 exerts its effects through binding to the prokineticin receptor 1 (PROKR1), a G protein-coupled receptor, triggering intracellular signaling pathways that influence various cellular processes. Its involvement extends beyond the gut, influencing diverse physiological functions, including cardiovascular development, stress response, and circadian rhythm.
Associated Diseases
- Irritable Bowel Syndrome (IBS)
- Constipation
- Gastroparesis
- Inflammatory Bowel Disease (IBD)
- Colon Cancer
- Neurodegenerative Disorders
- Sleep Disorders
- Obesity
Did you know?
Prokineticin-2 (PK2) is also known as Bv8, which stands for "brain-derived neurotrophic factor 8", highlighting its role in promoting neuronal survival and growth.
