PRKG2
Description
The PRKG2 gene encodes for cGMP-dependent protein kinase type II, a crucial enzyme involved in the regulation of smooth muscle contraction and relaxation. This protein acts as a molecular switch, responding to nitric oxide (NO) signaling by phosphorylating various downstream proteins. These phosphorylation events trigger a cascade of cellular responses, ultimately leading to smooth muscle relaxation. The PRKG2 gene plays a vital role in maintaining blood pressure, regulating blood flow, and controlling the contractions of various organs, including the uterus, bladder, and intestines.
Associated Diseases
- Hypertension
- Pulmonary Hypertension
- Erectile Dysfunction
- Premature Ejaculation
- Asthma
- Gastrointestinal Disorders
- Urinary Incontinence
Did you know?
Mutations in the PRKG2 gene are linked to a rare disorder called "familial isolated pulmonary hypertension", characterized by abnormally high blood pressure in the lungs.
