PRICKLE1 : prickle planar cell polarity protein 1

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Description

PRICKLE1 is a gene that encodes a protein involved in the Wnt signaling pathway, a crucial cellular communication system essential for various developmental processes. This pathway governs cell fate determination, tissue patterning, and organogenesis. PRICKLE1 protein functions as a negative regulator of Wnt signaling, ensuring proper pathway activation and preventing uncontrolled cell growth. Its role extends beyond development, influencing adult tissue homeostasis and potentially contributing to disease pathogenesis.

Associated Diseases

• Cancer (e.g., colorectal cancer, breast cancer)
• Neural tube defects
• Developmental abnormalities

Did you know?

PRICKLE1 gene mutations have been linked to specific types of human birth defects, highlighting its critical role in embryonic development.