POU1F1


Description

The POU1F1 (POU class 1 homeobox 1) is a protein-coding gene located on chromosome 3.

POU1F1, also known as PIT1, is a transcription factor crucial for the development and function of the anterior pituitary gland. It is responsible for the production of growth hormone, prolactin, and thyroid stimulating hormone. PIT1 binds to specific DNA sequences to regulate the expression of these hormones. It interacts with other proteins such as GATA2 and PITX1, further influencing its function.

Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Specifically binds to the consensus sequence 5'-TAAAT-3'. Activates growth hormone and prolactin genes.

POU1F1 is also known as CPHD1, GHF-1, PIT1, POU1F1a, Pit-1.

Associated Diseases


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