POLR1D : RNA polymerase I and III subunit D
Description
The POLR1D (RNA polymerase I and III subunit D) is a protein-coding gene located on chromosome 13.
The POLR1D gene provides instructions for making a subunit of two enzymes: RNA polymerase I and RNA polymerase III. These enzymes are crucial for RNA synthesis, particularly ribosomal RNA (rRNA), which is essential for protein production. RNA polymerase III also synthesizes other forms of RNA like transfer RNA (tRNA). The POLR1D gene's involvement in Treacher Collins syndrome suggests its critical role in early facial development.
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. It is a common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and short non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs, respectively.
POLR1D is also known as AC19, POLR1C, RPA16, RPA9, RPAC2, RPC16, RPO1-3, TCS2.
