PNPO : pyridoxamine 5'-phosphate oxidase
Description
The PNPO (pyridoxamine 5'-phosphate oxidase) is a protein-coding gene located on chromosome 17.
The PNPO gene provides instructions for producing an enzyme called pyridox(am)ine 5'-phosphate oxidase. This enzyme is involved in the breakdown (metabolism) of vitamin B6. Specifically, it chemically modifies two forms of vitamin B6 obtained from food (pyridoxine and pyridoxamine) to create pyridoxal 5'-phosphate (PLP). PLP is the active form of vitamin B6, and it is necessary for many chemical reactions in the body, including protein metabolism and the processing of chemicals that transmit signals in the brain (neurotransmitters). Pyridox(am)ine 5'-phosphate oxidase is active (expressed) in cells throughout the body, with the highest amounts found in the liver.
PNPO is also known as HEL-S-302, PDXPO.
