PLEKHG2
Description
The PLEKHG2 (pleckstrin homology and RhoGEF domain containing G2) is a protein-coding gene located on chromosome 19.
PLEKHG2 is a protein encoded by the PLEKHG2 gene in humans. It's a large protein with approximately 1300 amino acids and a molecular weight of 130 kDa. It contains a Dbl homology (DH) domain and a pleckstrin homology (PH) domain near the N-terminus. The DH domain is responsible for guanine nucleotide exchange activity, which converts GDP on the Rho family Small GTPase (RhoGTPase) to GTP. This makes PLEKHG2 act as a Rho-specific guanine nucleotide exchange factor (RhoGEF). Activation of RhoGTPase reorganizes the actin cytoskeleton and changes cell morphology, suggesting a role for PLEKHG2 in cell motility and neuronal network development through RhoGTPase and actin remodeling. The gene was first identified in a study of myeloid leukemia in mice, where it was found to be associated with the development of acute myelogenous leukemia.
PLEKHG2 is a potential oncogene that exhibits exchange activity with CDC42. It acts as a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42, and is activated by binding to beta and gamma subunits of the heterotrimeric G protein. PLEKHG2 plays a role in the regulation of actin polymerization. (UniProtKB:Q6KAU7, PubMed:18045877, PubMed:26573021)
PLEKHG2 is also known as ARHGEF42, CLG, CTB-60E11.4, LDAMD.
