PLA2G4A

Description

PLA2G4A, also known as group IVA cytosolic phospholipase A2, is a gene encoding an enzyme crucial for the metabolism of phospholipids. This enzyme plays a vital role in various cellular processes, including inflammation, cell signaling, and membrane remodeling. PLA2G4A catalyzes the hydrolysis of phospholipids, releasing arachidonic acid, a precursor to inflammatory mediators such as prostaglandins and leukotrienes. The gene‘s expression and activity are tightly regulated, ensuring proper cellular function.

Associated Diseases

• Neurological disorders: - Alzheimer‘s disease - Parkinson‘s disease - Amyotrophic lateral sclerosis (ALS)
• Cardiovascular diseases: - Atherosclerosis - Myocardial infarction
• Inflammatory diseases: - Asthma - Rheumatoid arthritis - Crohn‘s disease
• Cancer: - Colorectal cancer - Breast cancer

Did you know?

PLA2G4A is found in high concentrations in the brain, suggesting its important role in neuronal function.