PIK3CD : phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Description

The PIK3CD gene encodes for the catalytic subunit delta (p110δ) of phosphoinositide 3-kinase (PI3K), a critical enzyme family involved in various cellular processes. PI3Ks are lipid kinases that phosphorylate phosphatidylinositol (PI) lipids, generating second messengers that activate downstream signaling pathways. PIK3CD, specifically, plays a vital role in immune cell development, signaling, and function. It is activated by receptor tyrosine kinases (RTKs) and G protein-coupled receptors (GPCRs) and contributes to cell survival, proliferation, migration, and differentiation. Its dysregulation is linked to various diseases, highlighting its importance in maintaining cellular homeostasis.

Associated Diseases

• Cancer (particularly hematological malignancies like leukemia and lymphoma)
• Immune disorders (including autoimmune diseases)
• Inflammatory diseases
• Cardiovascular diseases
• Neurological disorders

Did you know?

PIK3CD is highly expressed in immune cells, particularly in B cells, T cells, and macrophages, making it a key regulator of immune responses.