PIGP
Description
The PIGP (phosphatidylinositol glycan anchor biosynthesis class P) is a protein-coding gene located on chromosome 21.
The PIGP gene encodes a protein subunit involved in the initial step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. GPI anchors are glycolipids found on numerous blood cells that attach proteins to the cell surface. PIGP is a component of the GPI-N-acetylglucosaminyltransferase complex, which catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). The PIGP gene is located in the Down syndrome critical region on chromosome 21, making it a potential contributor to Down syndrome. Multiple transcript variants encoding different isoforms of PIGP have been identified.
PIGP is part of the glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol. This process is the first step in GPI biosynthesis.
PIGP is also known as DCRC, DCRC-S, DEE55, DSCR5, DSRC, EIEE55, PIG-P.
