PIGB
Description
The PIGB (phosphatidylinositol glycan anchor biosynthesis class B) is a protein-coding gene located on chromosome 15.
The PIGB gene encodes a transmembrane protein located in the endoplasmic reticulum. This protein is involved in GPI-anchor biosynthesis, which is the process of attaching a glycolipid anchor to proteins, allowing them to be anchored to the cell surface. The GPI anchor is found on many blood cells and plays a crucial role in cell signaling and recognition. PIGB is thought to be part of a family of dolichol-phosphate-mannose (Dol-P-Man) dependent mannosyltransferases.
PIGB is a mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. It transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.
PIGB is also known as DEE80, EIEE80, GPI-MT-III, PIG-B.
