PGAM2 : phosphoglycerate mutase 2
Description
PGAM2, also known as Phosphoglycerate Mutase 2, is a crucial enzyme involved in glycolysis, the primary pathway for glucose breakdown in cells. It catalyzes the interconversion of 2-phosphoglycerate (2PG) and 3-phosphoglycerate (3PG), essential steps in energy production. PGAM2 plays a vital role in cellular metabolism, impacting diverse cellular processes like growth, proliferation, and apoptosis. Moreover, its dysfunction has been linked to various diseases, highlighting its significance in human health.
Associated Diseases
- Cancer (e.g., breast cancer, colorectal cancer, lung cancer)
- Neurological disorders (e.g., Alzheimer‘s disease, Parkinson‘s disease)
- Cardiovascular diseases (e.g., heart failure, atherosclerosis)
- Metabolic disorders (e.g., diabetes, obesity)
- Inflammatory diseases (e.g., rheumatoid arthritis, inflammatory bowel disease)
Did you know?
PGAM2 exists in two isoforms: PGAM2A and PGAM2B. PGAM2B is the predominant isoform expressed in most tissues and is crucial for glycolysis, while PGAM2A exhibits a distinct localization and function.
