PDE4D

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Description

The PDE4D gene encodes phosphodiesterase 4D, an enzyme that plays a crucial role in regulating intracellular levels of cyclic adenosine monophosphate (cAMP). cAMP is a second messenger involved in various cellular processes, including immune and inflammatory responses. PDE4D specifically hydrolyzes cAMP, reducing its concentration and modulating downstream signaling pathways. This enzyme is expressed in various cell types, particularly immune cells, and its activity is tightly controlled by various factors, including hormones, cytokines, and other signaling molecules.

Associated Diseases

• Asthma
• Chronic obstructive pulmonary disease (COPD)
• Inflammatory bowel disease (IBD)
• Rheumatoid arthritis
• Multiple sclerosis
• Sepsis
• Depression

Did you know?

Mutations in the PDE4D gene have been associated with increased susceptibility to asthma and other inflammatory disorders.