PDE10A

Description

The PDE10A (phosphodiesterase 10A) is a protein-coding gene located on chromosome 6.

PDE10A, encoded by the PDE10A gene, is an enzyme that regulates cellular responses by controlling the levels of the signaling molecules cAMP and cGMP. It breaks down these cyclic nucleotides into their inactive forms, thereby impacting intracellular signaling pathways. PDE10A inhibitors have been investigated as potential treatments for schizophrenia, as dysfunction in the striatum, where PDE10A is active, has been linked to this disorder. Research suggests a potential connection between PDE10A expression and obesity in both mice and humans. Notable inhibitors of PDE10A include Compound 96, Papaverine, PF-2545920, TAK-063, AMG 579, and CPL500036.

PDE10A plays a critical role in regulating the levels of cAMP and cGMP within cells, particularly in the striatum, a brain region vital for movement and cognition. It is known to break down both cAMP and cGMP, but exhibits a stronger preference for cAMP, demonstrating greater efficiency in its hydrolysis. This enzyme's activity is essential for proper cell signaling.

PDE10A is also known as ADSD2, HSPDE10A, IOLOD, LINC00473, PDE10A19.

Associated Diseases

• Dyskinesia, limb and orofacial, infantile-onset
• Striatal degeneration, autosomal dominant 2
• Infantile-onset generalized dyskinesia with orofacial involvement
• Childhood-onset benign chorea with striatal involvement