PAM16
Description
The PAM16 (presequence translocase associated motor 16) is a protein-coding gene located on chromosome 16.
PAM16, also known as TIM16, is a protein encoded by the PAM16 gene in humans. It‘s a key player in the import of proteins into the mitochondria, the cell‘s powerhouses. Located on chromosome 16, PAM16 produces a small protein with multiple roles. It regulates the movement of proteins into the mitochondria‘s inner compartment, a process that requires energy (ATP). PAM16 also prevents a protein called DNAJC19 from activating another protein, HSPA9, which is involved in energy production. This protein is important for a variety of cellular functions and mutations in the PAM16 gene have been linked to skeletal abnormalities. PAM16 interacts with several other proteins including PAM18, DNAJC19, TIMM17A, FEZ1, TRIM25, MARC1, and others.
PAM16 regulates the movement of proteins into the mitochondria‘s inner compartment, a process powered by ATP. It also prevents a protein called DNAJC19 from activating another protein, HSPA9, which is involved in energy production.
PAM16 is also known as CGI-136, MAGMAS, SMDMDM, TIM16, TIMM16.
