PADI3
Description
The PADI3 (peptidyl arginine deiminase 3) is a protein-coding gene located on chromosome 1.
The PADI3 gene provides instructions for making an enzyme called peptidylarginine deiminase type III. This enzyme modifies proteins by changing certain protein building blocks (amino acids). Specifically, it changes the positively charged amino acid arginine to the neutral amino acid citrulline in the presence of calcium ions. This process is called deimination. Deimination usually alters the protein‘s interactions with other proteins. Peptidylarginine deiminase type III is found in the skin‘s tough outer surface (the stratum corneum) within keratinocytes. It also functions in hair follicles, where it modifies proteins involved in hair shaft structure.
PADI3 is also known as PAD3, PDI3, UHS1.
