ORC6 : origin recognition complex subunit 6
Description
The ORC6 (origin recognition complex subunit 6) is a protein-coding gene located on chromosome 16.
The ORC6 gene encodes a protein essential for DNA replication, a process that copies a cell's DNA before division. This protein is part of the origin recognition complex (ORC), which binds to specific DNA regions called origins of replication, initiating DNA copying. ORC attracts other proteins to form the pre-replication complex, ensuring that DNA replication occurs only once per cell division. ORC6 also binds to heterochromatin, densely packed DNA with limited functional genes, although its function in this context remains unclear. Additionally, ORC6 plays a role in cytokinesis, the process separating dividing cells.
ORC6 is a component of the origin recognition complex (ORC) that binds to origins of replication, the specific DNA sequences that initiate DNA replication. This binding is dependent on ATP and facilitates the assembly of the pre-replication complex, which is essential for initiating DNA replication. Interestingly, ORC6 does not bind to histone H3 and H4 trimethylation marks, including H3K9me3, H3K27me3, and H4K20me3.
ORC6 is also known as ORC6L.
