LRRK2
Description
The LRRK2 gene, located on chromosome 12, encodes a large protein called leucine-rich repeat kinase 2. This protein plays a crucial role in various cellular functions, including protein degradation, autophagy, and neuronal signaling. Mutations in the LRRK2 gene are a common cause of familial Parkinson‘s disease, accounting for approximately 5% of cases. However, LRRK2‘s involvement extends beyond Parkinson‘s, with potential links to other neurodegenerative disorders, inflammatory diseases, and even cancer.
Associated Diseases
- Parkinson‘s disease
- Lewy body dementia
- Multiple system atrophy
- Alzheimer‘s disease
- Amyotrophic lateral sclerosis (ALS)
- Crohn‘s disease
- Cancer
Did you know?
LRRK2 is one of the largest known human genes, with over 8500 base pairs and encoding a protein containing over 2500 amino acids.
