NUP85
Description
NUP85, also known as Nucleoporin 85, is a crucial protein involved in the intricate process of nuclear transport. It resides within the nuclear pore complex (NPC), a massive protein structure embedded in the nuclear envelope, serving as a gateway for the selective movement of molecules between the nucleus and cytoplasm. NUP85‘s primary role is to regulate the passage of proteins and RNA, ensuring that only essential molecules enter the nucleus while preventing harmful substances from entering. This protein interacts with a diverse array of nuclear transport receptors, facilitating the transport of molecules through the NPC. NUP85‘s intricate structure, characterized by its distinct domains, allows for precise interactions with its partners, effectively controlling the flow of essential molecules into and out of the nucleus.
Associated Diseases
- Cancer (Leukemia, Breast Cancer, Prostate Cancer)
- Neurodevelopmental disorders (Intellectual disability, Autism Spectrum Disorder)
Did you know?
NUP85 is a highly conserved protein, meaning its structure and function are remarkably similar across different species, highlighting its fundamental importance in cellular life.
