NUAK2
Description
The NUAK2 gene, located on chromosome 1, encodes a serine/threonine protein kinase crucial for cellular processes like growth, metabolism, and autophagy. It acts as a central regulator, interacting with various signaling pathways to control cell fate and response to stress. NUAK2‘s diverse roles stem from its ability to phosphorylate a wide range of substrates, including those involved in energy production, protein synthesis, and cell survival. Understanding NUAK2‘s intricate mechanisms is essential for developing novel therapies for related diseases.
Associated Diseases
- Cancer (especially breast, colon, and lung)
- Diabetes
- Neurodegenerative diseases (e.g., Alzheimer‘s disease, Parkinson‘s disease)
- Cardiovascular diseases
- Obesity
Did you know?
NUAK2 has been shown to play a role in regulating the lifespan of the nematode worm C. elegans, suggesting its potential involvement in aging.
