NTRK3

Description

The NTRK3 gene encodes for the neurotrophic tyrosine kinase receptor type 3 (NTRK3) protein, a receptor tyrosine kinase involved in neuronal development and survival. This gene plays a crucial role in the nervous system, particularly in the brain and spinal cord. NTRK3 signaling pathways are activated by binding to neurotrophins, a family of growth factors that promote neuronal survival and differentiation. Mutations in the NTRK3 gene can lead to various diseases, including developmental disorders and certain types of cancer.

Associated Diseases

• Neurodevelopmental Disorders (e.g., intellectual disability, autism spectrum disorder)
• Neurodegenerative Diseases (e.g., Alzheimer‘s disease, Parkinson‘s disease)
• Cancer (e.g., neuroblastoma, melanoma, lung cancer)

Did you know?

NTRK3 gene mutations can be associated with an increased risk of developing certain types of cancer, highlighting the importance of understanding the role of this gene in cancer development.