NR3C1
Description
The NR3C1 gene encodes the glucocorticoid receptor (GR), a crucial protein involved in regulating stress response, metabolism, and immune function. Upon binding to glucocorticoid hormones like cortisol, GR acts as a transcription factor, modulating the expression of various genes. This intricate interplay affects diverse physiological processes, including energy balance, inflammation, and mood regulation.
Associated Diseases
- Cushing‘s syndrome
- Addison‘s disease
- Metabolic syndrome
- Depression
- Post-traumatic stress disorder (PTSD)
- Obesity
- Type 2 diabetes
- Asthma
- Rheumatoid arthritis
Did you know?
The NR3C1 gene is highly polymorphic, meaning it has many variations across individuals. These variations can influence the individual‘s sensitivity to stress and susceptibility to certain diseases.
