NNT : nicotinamide nucleotide transhydrogenase

Description

The NNT gene, encoding the enzyme nicotinamide nucleotide transhydrogenase (NNT), plays a crucial role in cellular metabolism. NNT catalyzes the transfer of reducing equivalents from NADPH to NAD+, a process vital for maintaining cellular redox balance and energy production. This gene is ubiquitously expressed, with significant activity in tissues like the liver, heart, and brain. NNT‘s critical role in maintaining cellular function makes it a potential target for therapeutic interventions aimed at addressing a range of metabolic and neurological disorders.

Associated Diseases

• Type 2 diabetes
• Obesity
• Neurodegenerative diseases (e.g., Alzheimer‘s disease, Parkinson‘s disease)
• Cardiovascular diseases
• Cancer

Did you know?

NNT is one of the largest human genes, spanning over 100,000 base pairs.