NHLRC1 : NHL repeat containing E3 ubiquitin protein ligase 1

Description

The NHLRC1 gene,  encodes a protein involved in the regulation of the immune system. It plays a crucial role in the activation and function of immune cells, specifically NK cells and T cells. NHLRC1 is a member of the NLRB family, which are known for their role in the interaction of immune cells with pathogens and the subsequent activation of immune responses. Mutations in the NHLRC1 gene can lead to a range of immune system dysregulation, potentially contributing to autoimmune disorders and increased susceptibility to infections.

Associated Diseases

• Autoimmune diseases (e.g., Systemic lupus erythematosus, Rheumatoid arthritis)
• Inflammatory bowel disease (IBD)
• Chronic inflammatory disorders
• Immunodeficiency disorders

Did you know?

NHLRC1 is expressed in a variety of immune cell types, including NK cells, T cells, and macrophages, suggesting its diverse role in immune regulation.