NEK9
Description
The NEK9 (NIMA related kinase 9) is a protein-coding gene located on chromosome 14.
NEK9, encoded by the NEK9 gene, is a serine/threonine-protein kinase involved in regulating various cellular processes. It interacts with NEK6, RAN, and SSRP1.
NEK9 plays a crucial role in regulating the progression of mitosis, particularly in spindle dynamics and chromosome separation. It has been shown to phosphorylate various substrates, including histones, myelin basic protein, beta-casein, and BICD2. NEK9 specifically phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. It is essential for the G1/S transition and S phase progression. Additionally, NEK9 phosphorylates NEK6 and NEK7, activating their function by releasing autoinhibitory domains. NEK9 forms homodimers, which are necessary for activating NEK7.
NEK9 is also known as APUG, LCCS10, NC, NERCC, NERCC1.
Associated Diseases
- Nevus comedonicus, somatic
- Nevus comedonicus syndrome
- Arthrogryposis, perthes disease, and upward gaze palsy
- Lethal congenital contracture syndrome 10
