NEK2
Description
The NEK2 (NIMA related kinase 2) is a protein-coding gene located on chromosome 1.
Serine/threonine-protein kinase Nek2 is an enzyme that in humans is encoded by the NEK2 gene. NEK2 has been shown to interact with MAPK1 and NDC80.
NEK2 is involved in the regulation of centrosome separation and bipolar spindle formation during mitosis, as well as chromatin condensation during meiosis. It regulates centrosome separation by phosphorylating centrosomal proteins such as CROCC, CEP250, and NINL, which leads to their displacement from the centrosomes. NEK2 also regulates kinetochore microtubule attachment stability in mitosis by phosphorylating NDC80. It is involved in the regulation of the mitotic checkpoint protein complex by phosphorylating CDC20 and MAD2L1. NEK2 plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. It phosphorylates PPP1CC, SGO1, NECAB3, and NPM1. NEK2 is essential for the localization of MAD2L1 to the kinetochore and MAPK1 and NPM1 to the centrosome. It phosphorylates CEP68 and CNTLN directly or indirectly, which promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis. NEK2 is involved in the regulation of centrosome disjunction. It phosphorylates CCDC102B either directly or indirectly, which causes CCDC102B to dissociate from the centrosome and allows for centrosome separation. {ECO:0000269|PubMed:11742531, ECO:0000269|PubMed:12857871, ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:15358203, ECO:0000269|PubMed:15388344, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:17626005, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18297113, ECO:0000269|PubMed:20034488, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:30404835}
NEK2 is also known as HsPK21, NEK2A, NLK1, PPP1R111, RP67.
