NDUFS7

Description

The NDUFS7 gene encodes a subunit of NADH dehydrogenase (ubiquinone) 1, also known as complex I, a crucial component of the mitochondrial electron transport chain (ETC). This complex plays a central role in cellular respiration, the process by which cells generate energy from nutrients. NDUFS7‘s function is essential for the transfer of electrons from NADH to ubiquinone, driving the production of ATP, the primary energy currency of cells. Mutations in this gene can disrupt the ETC, leading to various mitochondrial diseases.

Associated Diseases

• Leigh syndrome
• Mitochondrial encephalomyopathy
• Mitochondrial complex I deficiency
• Hypertrophic cardiomyopathy

Did you know?

NDUFS7 is a highly conserved gene, meaning its sequence is very similar across different species, highlighting its critical role in cellular function.