NDUFA10
Description
NDUFA10 is a gene that provides instructions for making a protein called NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10. This protein is a crucial subunit of Complex I, the first enzyme in the mitochondrial electron transport chain (ETC). The ETC plays a pivotal role in cellular respiration, the process by which cells generate energy in the form of ATP. Complex I facilitates the transfer of electrons from NADH to ubiquinone, a critical step in the production of ATP. Mutations in the NDUFA10 gene can disrupt the function of Complex I, leading to a deficiency in cellular energy production, which can have severe consequences for various tissues and organs.
Associated Diseases
- Leigh syndrome
- Mitochondrial complex I deficiency
- Neurological disorders
- Cardiomyopathy
- Hepatic dysfunction
- Myopathy
Did you know?
NDUFA10 is one of the largest genes in the human genome, spanning over 100,000 base pairs.
