NDRG1
Description
The NDRG1 (N-myc downstream regulated 1) is a protein-coding gene located on chromosome 8.
NDRG1 is a protein encoded by the NDRG1 gene in humans. It belongs to the N-myc downregulated gene family, which is part of the alpha/beta hydrolase superfamily. NDRG1 is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. Mutations in this gene have been linked to the autosomal-recessive form of Charcot-Marie-Tooth disease known as CMT4D. NDRG1 localizes to the endosomes and acts as a Rab4a effector involved in vesicular recycling. NDRG1 is involved in various biological processes, including embryogenesis and development, cell growth and differentiation, lipid biosynthesis and myelination, stress responses, immunity, DNA repair, and cell adhesion. NDRG1 is found in the cytoplasm, nucleus, and mitochondrion. In response to DNA damage, it translocates from the cytoplasm to the nucleus, where it may inhibit cell growth and promote DNA repair mechanisms. NDRG1 is considered a stress response gene or potentially a transcription factor. The NDRG1 gene is located on chromosome 8 (8q24.22) and encodes a 3.0 kilobases (kb) messenger RNA (mRNA) composed of 394 amino acids.
NDRG1 is a stress-responsive protein involved in hormone responses, cell growth, and differentiation. It acts as a tumor suppressor in many cell types and is necessary, but not sufficient, for p53/TP53-mediated caspase activation and apoptosis. NDRG1 plays a role in cell trafficking, particularly in Schwann cells, and is essential for the maintenance and development of the peripheral nerve myelin sheath. It is required for vesicular recycling of CDH1 and TF and may also function in lipid trafficking. NDRG1 protects cells from spindle disruption damage and functions in the p53/TP53-dependent mitotic spindle checkpoint. It regulates microtubule dynamics and maintains euploidy.
NDRG1 is also known as CAP43, CMT4D, DRG-1, DRG1, GC4, HMSNL, NDR1, NMSL, PROXY1, RIT42, RTP, TARG1, TDD5.
