NDE1
Description
The NDE1 (nudE neurodevelopment protein 1) is a protein-coding gene located on chromosome 16.
The NDE1 gene encodes a protein known as Nuclear distribution protein nudE homolog 1. Mutations in both copies of the NDE1 gene are linked to a condition called microlissencephaly type 4.
NDE1 plays a crucial role in the duplication and formation of centrosomes, essential structures involved in cell division, and the proper functioning of the mitotic spindle. It is essential for the development of the cerebral cortex, a vital part of the brain. NDE1 may regulate the production of neurons by controlling the orientation of the mitotic spindle during the division of cortical neuronal progenitors in the proliferative ventricular zone of the brain. This orientation dictates whether the division results in two proliferative progenitors (perpendicular orientation) or one progenitor and a mature neuron (parallel orientation). A premature shift towards a neuronal fate within the progenitor population can lead to a decrease in the total number of neurons and an increase in the number of neurons in the deeper layers of the cortex.
NDE1 is also known as HOM-TES-87, LIS4, MHAC, NDE, NUDE, NUDE1.
