NCF4 : neutrophil cytosolic factor 4
Description
The NCF4 (neutrophil cytosolic factor 4) is a protein-coding gene located on chromosome 22.
The NCF4 gene provides instructions for making neutrophil cytosolic factor 4 (NCF4), also known as p40-phox. NCF4 is a subunit of the NADPH oxidase enzyme complex, which is critical for the immune system's ability to fight off infections. Specifically, NADPH oxidase is active in phagocytes, cells that engulf and destroy foreign invaders like bacteria and fungi. The enzyme converts oxygen into superoxide, a toxic molecule that is used to generate other reactive oxygen species (ROS) like hydrogen peroxide and hypochlorous acid. These ROS are potent disinfectants that help phagocytes eliminate pathogens. NCF4's role in the NADPH oxidase complex is likely important for assembling and activating the complex, ensuring that ROS production is properly regulated.
NCF4 is also known as CGD3, NCF, P40PHOX, SH3PXD4.
