NCAPD2
Description
The NCAPD2 (non-SMC condensin I complex subunit D2) is a protein-coding gene located on chromosome 12.
NCAPD2, also known as CAP-D2, is a protein that is encoded by the NCAPD2 gene in humans. It is a subunit of condensin I, a large protein complex involved in chromosome condensation.
NCAPD2 is a regulatory subunit of the condensin complex, which is essential for the conversion of interphase chromatin into condensed chromosomes during mitosis. The condensin complex likely introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases, and converts nicked DNA into positively knotted forms in the presence of type II topoisomerases. NCAPD2 may target the condensin complex to DNA via its C-terminal domain and may promote the resolution of double-strand DNA catenanes between sister chromatids. Condensin-mediated compaction increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges, leading to chromatid decatenation. NCAPD2 is required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, NCAPD2 plays a crucial role in ensuring accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.
NCAPD2 is also known as CAP-D2, CNAP1, MCPH21, hCAP-D2.
