MYO5B : myosin VB
Description
The MYO5B (myosin VB) is a protein-coding gene located on chromosome 18.
The MYO5B gene provides instructions for creating a protein called myosin Vb. This protein is part of a group of proteins known as myosins, which share similar structures and are involved in cell movement and transporting materials within and between cells. Myosin Vb helps determine the position of various components within cells (cell polarity). Myosin Vb also plays a role in moving components from the cell membrane to the interior of the cell for recycling.
Myosin Vb is involved in vesicular trafficking, particularly through its association with the CART complex. This complex is crucial for the efficient recycling of transferrin receptors but doesn't play a role in EGFR degradation. Myosin Vb collaborates with RAB11A and RAB11FIP2 to transport NPC1L1 to the plasma membrane. In partnership with RAB11A, it contributes to CFTR trafficking to the plasma membrane and transferrin recycling in non-polarized cells. Alongside RAB11A and RAB8A, it participates in epithelial cell polarization. Myosin Vb, along with RAB25, regulates transcytosis. It is essential for the accurate positioning of the bile salt export pump ABCB11 at the apical/canalicular plasma membrane of hepatocytes.
MYO5B is also known as DIAR2, MVID1, PFIC10.
Associated Diseases
- Diarrhea 2, with microvillous atrophy
- Microvillus inclusion disease
- Cholestasis, progressive familial intrahepatic, 10
