MYL9
Description
The MYL9 (myosin light chain 9) is a protein-coding gene located on chromosome 20.
Myosin regulatory light polypeptide 9 is a protein that in humans is encoded by the MYL9 gene. Myosin, a structural component of muscle, consists of two heavy chains and four light chains. The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for this gene.
Myosin regulatory light polypeptide 9 (MYL9) is a key component of myosin, a protein complex responsible for muscle contraction. MYL9 plays a crucial role in regulating both smooth muscle and nonmuscle cell contractile activity by undergoing phosphorylation. This phosphorylation process modulates the activity of myosin, impacting various cellular processes including cell division (cytokinesis), receptor movement (receptor capping), and cell movement (cell locomotion). Evidence suggests that MYL9 also participates in the formation of muscle fibers (myotubes) in developing muscle cells (myoblasts) by influencing the assembly of a specific protein complex (actomyosin) regulated by a mechanosensitive ion channel (PIEZO1).
MYL9 is also known as LC20, MLC-2C, MLC2, MMIHS4, MRLC1, MYRL2.
