MSH3
Description
The MSH3 gene provides instructions for making a protein that plays a crucial role in DNA mismatch repair (MMR). This repair system corrects errors that occur during DNA replication, ensuring the accuracy of genetic information. MSH3, along with other MMR proteins, scans newly replicated DNA for mismatched base pairs and insertion/deletion loops. It then recruits other proteins to initiate the repair process, ultimately preventing mutations and maintaining genomic stability. Defects in the MSH3 gene can lead to a compromised MMR system, increasing the risk of developing various cancers and other genetic disorders.
Associated Diseases
- Lynch syndrome (Hereditary Nonpolyposis Colorectal Cancer)
- Endometrial cancer
- Ovarian cancer
- Stomach cancer
- Small bowel cancer
- Bile duct cancer
- Brain tumors
- Leukemia
Did you know?
MSH3 gene mutations are more common in individuals with a family history of Lynch syndrome, suggesting a genetic predisposition to this condition.
