MMP21
Description
The MMP21 gene, also known as collagenase-3 or MMP-3, is a crucial component of the matrix metalloproteinase (MMP) family. These enzymes play a vital role in breaking down extracellular matrix (ECM) components, a process essential for tissue remodeling during development, wound healing, and various physiological processes. MMP21 specifically targets collagen type I, the most abundant protein in the body, and its activity is tightly regulated to ensure proper tissue homeostasis. Dysregulation of MMP21 expression can lead to various pathological conditions, highlighting its importance in human health.
Associated Diseases
- Cancer (various types, including breast, colon, and lung cancer)
- Arthritis (rheumatoid arthritis, osteoarthritis)
- Cardiovascular diseases (atherosclerosis, heart failure)
- Wound healing complications
- Pulmonary fibrosis
- Periodontitis
Did you know?
MMP21 is unique among MMPs because it lacks a hemopexin domain, a structure typically involved in binding to ECM components and regulating enzymatic activity.
