MMP2 : matrix metallopeptidase 2


Description

MMP2, also known as gelatinase A, is a zinc-dependent endopeptidase that plays a critical role in extracellular matrix (ECM) degradation. It belongs to the matrix metalloproteinase (MMP) family, a group of enzymes involved in tissue remodeling, wound healing, and various physiological and pathological processes. MMP2‘s primary function is to break down collagen, a major component of ECM, facilitating cell migration, angiogenesis, and tissue repair. However, MMP2‘s activity is tightly regulated, and its dysregulation can contribute to various diseases.

Associated Diseases

Did you know?

MMP2 is activated by a unique mechanism involving the interaction with its pro-domain and TIMP-2 (tissue inhibitor of metalloproteinases-2). This activation process is crucial for maintaining the delicate balance between ECM degradation and tissue integrity.


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