MFN2 : mitofusin 2

Description

The MFN2 gene, provides instructions for making a protein called mitofusin-2. This protein is crucial for the fusion of mitochondria, the powerhouses of our cells. Mitochondrial fusion is essential for maintaining healthy mitochondria, ensuring proper energy production and preventing cell death. Mutations in the MFN2 gene can disrupt mitochondrial fusion, leading to a range of neurological disorders.

Associated Diseases

• Charcot-Marie-Tooth disease type 2A (CMT2A)
• Axonal Charcot-Marie-Tooth disease
• Dominant optic atrophy (DOA)
• Hereditary spastic paraplegia (HSP)
• Leigh syndrome
• Mitochondrial myopathy

Did you know?

Mutations in the MFN2 gene are associated with a wide spectrum of neurological disorders, highlighting the crucial role of mitochondrial fusion in maintaining neuronal health.