MEIOB
Description
The MEIOB (meiosis specific with OB-fold) is a protein-coding gene located on chromosome 16.
MEIOB is a single-stranded DNA-binding protein essential for homologous recombination during meiosis I. It plays a crucial role in repairing double-strand breaks (DSBs), facilitating crossover formation, and ensuring accurate and complete synapsis. While not involved in the initial loading of recombinases, MEIOB is vital for maintaining the appropriate number of RAD51 and DMC1 foci after the zygotene stage. It likely stabilizes recombinases, enabling efficient homology search and meiotic recombination. MEIOB exhibits 3'-5' exonuclease activity on single-stranded DNA in vitro.
MEIOB is also known as C16orf73, POF23, SPGF22, gs129.
Associated Diseases
- Spermatogenic failure 22
- Male infertility with azoospermia or oligozoospermia due to single gene mutation
- Premature ovarian failure 23
