MCM3AP
Description
The MCM3AP (minichromosome maintenance complex component 3 associated protein) is a protein-coding gene located on chromosome 21.
80 kDa MCM3-associated protein is a protein that in humans is encoded by the MCM3AP gene.
== Function == The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is an MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization.
== Interactions == MCM3AP has been shown to interact with:
MCM3 and TRIB3.
As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations.
MCM3AP is also known as GANP, MAP80, PNRIID, SAC3.
