MC2R : melanocortin 2 receptor


Description

The melanocortin 2 receptor (MC2R) gene plays a crucial role in regulating pigmentation, stress response, and energy metabolism. It encodes a G protein-coupled receptor that binds to melanocortin hormones, primarily adrenocorticotropic hormone (ACTH), triggering a cascade of intracellular signaling pathways. ACTH, released from the pituitary gland, stimulates the adrenal glands to produce cortisol, a hormone vital for managing stress, blood sugar, and immune function. Additionally, MC2R influences pigmentation by regulating melanin production in melanocytes, the cells responsible for skin, hair, and eye color.

Associated Diseases

Did you know?

The MC2R gene is highly conserved across species, suggesting its fundamental importance in regulating physiological processes.


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