MBOAT7
Description
The MBOAT7 (membrane bound O-acyltransferase domain containing 7) is a protein-coding gene located on chromosome 19.
MBOAT7 (Membrane-bound O-acyltransferase domain-containing protein 7) is an enzyme encoded by the MBOAT7 gene in humans. It belongs to the membrane-bound O-acyltransferase family, which are integral membrane proteins with acyltransferase activity. MBOAT7 acts as a lysophosphatidylinositol acyltransferase, specifically utilizing arachidonoyl-CoA as an acyl donor. This protein participates in the re-acylation of phospholipids as part of the phospholipid remodeling pathway known as the Lands cycle.
MBOAT7 catalyzes the transfer of an acyl group from an acyl-CoA to lysophosphatidylinositol (LPI), producing phosphatidylinositol (PI) and participating in the Lands cycle phospholipid remodeling pathway. MBOAT7 preferentially uses arachidonoyl-CoA as the acyl donor, contributing to the regulation of free arachidonic acid levels in cells. In the liver, MBOAT7 regulates triglyceride metabolism through phosphatidylinositol acyl-chain remodeling.
MBOAT7 is also known as BB1, LENG4, LPIAT, LPIAT1, LPLAT, LPLAT11, LRC4, MBOA7, MRT57, OACT7, hMBOA-7.
