MAP3K20
Description
The MAP3K20 (mitogen-activated protein kinase kinase kinase 20) is a protein-coding gene located on chromosome 2.
MAP3K20 is a stress-activated protein kinase that plays a role in programmed cell death. It is involved in signaling pathways activated by various stresses, including ribosomal stress, osmotic shock, and ionizing radiation. MAP3K20 activates the JNK and p38 MAP kinase pathways by phosphorylating MAP kinase kinases. It is also involved in stress associated with adrenergic stimulation, contributing to cardiac decompensation during periods of acute cardiac stress. MAP3K20 may regulate the S and G2 cell cycle checkpoint by phosphorylating CHEK2. It acts as a proximal sensor of ribosome collisions during the ribotoxic stress response, directly binding to the ribosome and activating either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR). MAP3K20 is also part of the stress-activated protein kinase signaling cascade that triggers the NLRP1 inflammasome in response to UV-B irradiation. It can also act as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph).
MAP3K20 is also known as AZK, CNM6, MLK7, MLT, MLTK, MLTKalpha, MLTKbeta, MRK, SFMMP, ZAK, mlklak, pk.
Associated Diseases
- Split-foot malformation-mesoaxial polydactyly syndrome
- Myopathy, centronuclear, 6, with fiber-type disproportion
- Congenital fiber-type disproportion myopathy
- Split-Foot malformation with mesoaxial polydactyly
