MALT1
Description
The MALT1 gene encodes a protein that plays a critical role in the immune system. It acts as a scaffold protein, bringing together other proteins to form complexes involved in crucial signaling pathways, particularly those triggered by the T cell receptor (TCR). These pathways are essential for immune responses, including the activation of lymphocytes and the production of cytokines. MALT1 also plays a part in regulating inflammation and cell death. Dysregulation of MALT1 activity can lead to autoimmune disorders and certain types of cancer, highlighting its importance in maintaining immune homeostasis.
Associated Diseases
- Autoimmune Disorders (e.g., Systemic Lupus Erythematosus, Rheumatoid Arthritis)
- Lymphoma (e.g., Mantle Cell Lymphoma, Diffuse Large B-Cell Lymphoma)
- Chronic Inflammatory Diseases (e.g., Crohn‘s Disease, Inflammatory Bowel Disease)
- Cancer (e.g., Multiple Myeloma, Leukemia)
Did you know?
MALT1 was initially discovered in a type of lymphoma called mucosa-associated lymphoid tissue lymphoma (MALT lymphoma), hence its name.
