MALT1

Description

The MALT1 gene encodes a protein that plays a critical role in the immune system. It acts as a scaffold protein, bringing together other proteins to form complexes involved in crucial signaling pathways, particularly those triggered by the T cell receptor (TCR). These pathways are essential for immune responses, including the activation of lymphocytes and the production of cytokines. MALT1 also plays a part in regulating inflammation and cell death. Dysregulation of MALT1 activity can lead to autoimmune disorders and certain types of cancer, highlighting its importance in maintaining immune homeostasis.

Associated Diseases

• Autoimmune Disorders (e.g., Systemic Lupus Erythematosus, Rheumatoid Arthritis)
• Lymphoma (e.g., Mantle Cell Lymphoma, Diffuse Large B-Cell Lymphoma)
• Chronic Inflammatory Diseases (e.g., Crohn‘s Disease, Inflammatory Bowel Disease)
• Cancer (e.g., Multiple Myeloma, Leukemia)

Did you know?

MALT1 was initially discovered in a type of lymphoma called mucosa-associated lymphoid tissue lymphoma (MALT lymphoma), hence its name.