MAK
Description
The MAK (male germ cell associated kinase) is a protein-coding gene located on chromosome 6.
MAK, also known as Male germ cell-associated kinase, is a human protein that plays a crucial role in various cellular processes. It is involved in regulating ciliary length, ensuring the long-term survival of photoreceptors, and participating in cell cycle regulation by phosphorylating FZR1. MAK also contributes to the transcriptional coactivation of AR, suggesting its potential role in spermatogenesis. Furthermore, its involvement in chromosomal stability in prostate cancer cells highlights its potential importance in cancer biology. MAK interacts with multiple proteins, including RP1, AR, CDK20, and FZR1, forming complex networks that underpin its diverse functions.
Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors. Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells.
MAK is also known as RP62.
