MAD2L2
Description
The MAD2L2 (mitotic arrest deficient 2 like 2) is a protein-coding gene located on chromosome 1.
MAD2L2 encodes the mitotic spindle assembly checkpoint protein MAD2B. MAD2L2 is part of the mitotic spindle assembly checkpoint that ensures all chromosomes are properly aligned before anaphase begins. MAD2L2 is a homolog of MAD2L1.
MAD2L2 is an adapter protein that interacts with various other proteins and is involved in a wide range of biological processes, including DNA repair, cell cycle regulation, and gene transcription. It plays a key role in translesion DNA synthesis by mediating the interaction between REV3L and REV1, two DNA polymerases involved in replicating damaged DNA. MAD2L2 is also a component of the shieldin complex, which is crucial for repairing double-stranded breaks in DNA. This complex promotes non-homologous end joining (NHEJ) during the G1 and S phases of the cell cycle. MAD2L2 further regulates cell cycle progression by inhibiting the activation of the anaphase promoting complex (APC) through its interaction with FZR1 and possibly CDC20. It also modulates gene transcription by interacting with TCF7L2, potentially contributing to epithelial-mesenchymal transdifferentiation. In addition, MAD2L2 may regulate cellular responses to DNA damage by influencing the phosphorylation and activation of the transcription factor ELK1 via the JNK pathway.
MAD2L2 is also known as FANCV, MAD2B, POLZ2, REV7.
