LYST : lysosomal trafficking regulator
Description
The LYST (lysosomal trafficking regulator) is a protein-coding gene located on chromosome 1.
The LYST gene provides instructions for making a protein called the lysosomal trafficking regulator. This protein is believed to be involved in the transport of materials into lysosomes, which are cellular recycling centers. Lysosomes use enzymes to break down toxic substances, digest bacteria, and recycle worn-out cell components. While the exact role of the lysosomal trafficking regulator protein is unknown, studies suggest it may influence the size of lysosomes and control their movement within cells.
LYST protein acts as an adapter protein, regulating the fission of intracellular vesicles, particularly lysosomes. It might also play a role in the trafficking of proteins involved in exocytosis. In immune cells like cytotoxic T-cells and natural killer cells, LYST controls the size, number, and release of lytic granules. In macrophages and dendritic cells, LYST is involved in phagosome maturation, directing the transition from early to late phagosomes. It also regulates the TLR3 and TLR4 signaling pathways in these cells, impacting the production of pro-inflammatory cytokines. LYST interacts with proteins like CENPJ, LIP8, and ZNF521.
LYST is also known as CHS, CHS1, Mauve.
