LMNB2
Description
The LMNB2 (lamin B2) is a protein-coding gene located on chromosome 19.
Lamin B2 is a protein encoded by the LMNB2 gene in humans. It is one of the two type B nuclear lamins and is associated with laminopathies, a group of genetic disorders affecting the nuclear envelope.
LMNB2 encodes a protein called Lamin B2, which is a type of intermediate filament protein that forms a network called the nuclear lamina. The nuclear lamina is a fibrous layer located on the inside of the nuclear membrane, providing structural support to the nucleus. It plays a crucial role in the assembly of the nucleus, organizing chromatin, and regulating the dynamics of the nuclear membrane and telomeres. The structural integrity of the nuclear lamina is closely tied to the cell cycle, as it disassembles during prophase and reassembles during telophase.
LMNB2 is also known as EPM9, LAMB2, LMN2, MCPH27.
Associated Diseases
- Lipodystrophy, partial, acquired, susceptibility to
- Epilepsy, progressive myoclonic, 9
- Microcephaly 27, primary, autosomal dominant
- Acquired partial lipodystrophy
