LIPE
Description
The LIPE (lipase E, hormone sensitive type) is a protein-coding gene located on chromosome 19.
LIPE may refer to:
LIPE, also known as hormone-sensitive lipase (HSL), is a broad-spectrum lipase that breaks down various lipids, including triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters, and retinyl esters. It exhibits a preference for DAGs over TAGs and MAGs, primarily hydrolyzing fatty acid (FA) esters at the sn-3 position of the glycerol backbone in DAGs. In TAGs, it preferentially hydrolyzes FA esters at the sn-1 and sn-2 positions. LIPE also hydrolyzes 2-arachidonoylglycerol, an endocannabinoid, and 2-acetyl monoalkylglycerol ether, a precursor for platelet-activating factor synthesis. In adipose tissue and the heart, LIPE primarily breaks down stored triglycerides into free fatty acids, while in steroidogenic tissues, it converts cholesteryl esters into free cholesterol for steroid hormone production.
LIPE is also known as AOMS4, FPLD6, HSL, LHS, REH.
